Sub-set of stem cells found to minimize risks when used to treat damaged hearts
Myocardial infarction -- better known as a heart attack--strikes on average every 43 seconds in America. This has motivated novel cardiotherapeutic strategies to repair and regenerate heart muscle, including human mesenchymal stem cell (hMSC) therapy. However, in clinical trials the benefits have often been modest and transient, which reflects our limited mechanistic knowledge of how hMSCs impact cardiac function. Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy. Their computer simulations demonstrate that one family of human mesenchymal stem cells minimizes disturbances in cardiac single-cell and tissue level electrical activity. By identifying the benefits of using this specific sub-set of human mesenchy...